1027833-17-5

Basic information

• Product Name: 1-Bromo-2-chloro-5-fluoro-4-nitrobenzene
• Synonyms: 1-Bromo-2-chloro-5-fluoro-4-nitrobenzene;4-Bromo-5-chloro-2-fluoronitrobenzene;Benzene, 1-bromo-2-chloro-5-fluoro-4-nitro-
• CAS NO: 1027833-17-5
• Molecular Formula: C₆H₂BrClFNO₂
• Molecular Weight: 254.4409832
• Mol File: 1027833-17-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 291.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.904±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-Bromo-2-chloro-5-fluoro-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-chloro-5-fluoro-4-nitrobenzene(1027833-17-5)
• EPA Substance Registry System: 1-Bromo-2-chloro-5-fluoro-4-nitrobenzene(1027833-17-5)

Safety Data

• Hazardous Substances Data: 1027833-17-5(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-chloro-5-fluoro-4-nitrobenzene is a specialized chemical compound. It has the molecular formula C6H2BrClFNO2, indicating that it consists of carbon atoms, hydrogen atoms, bromine, chlorine, fluorine, nitrogen, and oxygen atoms in specific ratios. This halogenated derivative of benzene is notable for the range of halogens it incorporates, specifically bromine, chlorine, and fluorine atoms along with one nitro group (-NO2) attached to the benzene ring. It is typically used in organic synthesis, meaning that it's often used as a building block to produce more complex organic compounds in laboratory or industrial environments. Properties can vary depending on the compound's specific structure and chemical environment, and it should be handled with caution due to it being a potential precursor to more hazardous substances.

InChI:InChI=1S/C6H2BrClFNO2/c7-3-1-5(9)6(10(11)12)2-4(3)8/h1-2H

Upstream product

• 201849-15-2 2-bromo-1-chloro-4-fluoro-benzene 

Downstream Products

• 1228376-68-8 4-amino-2-chloro-5-fluoro-benzonitrile 
• 116369-24-5 4-bromo-5-chloro-2-fluoroaniline 
• 1360616-77-8 1-bromo-2-chloro-5-methoxy-4-nitro-benzene 
• 1437716-04-5 1-bromo-2-chloro-5-isopropoxy-4-nitro-benzene 
• 1437870-64-8 N-(2-(2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl)-ethyl)-2-morpholin-4-yl-acetamide 
• 1437718-00-7 N-[2-(4-amino-2-chloro-5-methoxy-phenyl)-ethyl]-2-morpholin-4-yl-acetamide 
• 1437717-92-4 N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-2-morpholin-4-yl-acetamide 
• 1437717-84-4 2-chloro-N-[2-(2-chloro-5-methoxy-4-nitro-phenyl)-ethyl]-acetamide 
• 1437717-77-5 (R)-2-(2-{2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-5-methoxy-phenyl}-ethylcarbamoyl)-morpholine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING

The invention is directed to compounds of the formula: wherein each of the variables are defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance treating an autoimmune disease.

Pharmaceutically Active Pyrazine Derivatives

The invention provides compounds which inhibit or modulate the activity of Chk-1 kinase and which are useful in the treatment of cancer. The compounds have the general formula (1): and salts, N-oxides and tautomers thereof, wherein m is 2, 3 or 4; n is 0

PHARMACEUTICAL COMPOUNDS

The invention provides a compound of the formula (1): or a salt, N-oxide or tautomer thereof; wherein R1 is cyano or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 and R5 are the same or different and each is selected from hydrogen, saturated C1-4 hydrocarbyl and saturated C1-4 hydrocarbyloxy; R6 and R7 are the same or different and each is selected from hydrogen, halogen, CN, C1-4 alkyl and C1-4 alkoxy wherein the C1-4 alkyl and C1-4 alkoxy are each optionally substituted with hydroxy, C1-2 alkoxy or by one or more flourine atoms; R8 is hydrogen or C1-4 alkyl; Q is an alkylene chain of 1 to 4 carbon atoms in length between the moiety Ar and the nitrogen atom N, wherein one or more of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with one or two C1-4 alkyl groups, or wherein one carbon atom of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with a group -CH2CH2- which together with the said one carbon atom forms a cyclopropyl group; m is 1, 2, 3 or 4; n is 0 or 1; and Ar is a monocyclic or bicyclic aryl or heteroaryl group of 5 to 10 ring members containing 0, 1, 2, 3 or 4 heteroatom ring members selected from O, N and S, the aryl or heteroaryl group being optionally substituted with one to four substituents R13 as defined in the claims. The compounds are inhibitors of Chk-1 kinase and are active against cancers.