1028-37-1

Usage

Structure

Quinazoline backbone with a methyl and phenyl group attached

Use

Anti-inflammatory and analgesic agent

Conditions Treated

Rheumatoid arthritis, osteoarthritis, and other inflammatory diseases

Mechanism of Action

Inhibits the production of prostaglandins responsible for pain and inflammation

Clinical Studies

Shown promising results in pain management and inflammation treatment

Potential Development

May be developed into a new and effective medication for pain management and inflammation

Further Research

Needed to fully understand its mechanism of action and potential side effects

Upstream product

• 57266-65-6 3-phenyl-hexahydro-quinazoline-2,4-dione 
• 74-88-4 methyl iodide 
• 119-68-6 N-Methylanthranilic acid 
• 5416-30-8 N,N'-diphenyl-S-methyl isothiourea 
• 10328-92-4 N-Methylisatoic anhydride 
• 103-71-9 phenyl isocyanate 
• 103-72-0 phenyl isothiocyanate 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 37029-30-4 N-(3,4-Dihydro-4-oxo-3-phenylquinazolin-2-ylmercaptoacetyl)hydrazine 
• 28831-35-8 (3-phenyl-4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)acetic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 603-23-6 3-phenyl-2,4-(1H,3H)-quinazolinedione 

Relevant academic research and scientific papers

Pd(ii)-Catalyzed [4 + 1 + 1] cycloaddition of simple: O -aminobenzoic acids, CO and amines: Direct and versatile synthesis of diverse N -substituted quinazoline-2,4(1 H,3 H)-diones

The mild, efficient, and straightforward synthesis of pharmaceutically and biologically active N3-substituted and N1,N3-disubstituted quinazoline-2,4-(1H,3H)-diones from simple and readily available substrates has been a huge challenge. Described here is a Pd(ii)-catalyzed [4 + 1 + 1] modular synthesis of diverse quinazoline-2,4-(1H,3H)-diones through one-pot cascade reactions of cyclocondensation of o-(alkyl)aminobenzoic acids with CO, amidation of the intermediate isatoic anhydrides with amines, and unprecedented carbonylation of the resulting o-aminobenzamides with CO under 1 atm and 60 °C conditions. The chemoselective and versatile multicomponent reaction allows for the diversities of the products including N3-substituted and N1,N3-disubstituted products, and even makes the substituents on N1,N3 the same or different from each other, which cannot be achieved by most traditional synthetic strategies. This journal is

Method for synthesizing quinazoline-2, 4 (1H, 3H)-diketone compound

The invention discloses a method for synthesizing a quinazoline-2, 4 (1H, 3H)-diketone compound, and belongs to the technical field of synthesis of nitrogen-containing heterocyclic compounds. According to the technical scheme, the method is characterized in that an anthranilic acid compound and an amine compound serve as reaction raw materials, CO serves as a carbonylation reagent, Pd (II) servesas a catalyst, KI or KI/AcOH serves as an additive, Cu (OAc) 2 or O2 or Cu (OAc) 2/O2 serves as an oxidizing agent, and the target product quinazoline-2, 4 (1H, 3H)-diketone compound is prepared through a one-pot multi-component reaction. The method has the advantages of simple and easily available raw material, short synthesis route, high atom economy and step economy, mild reaction conditions, diversified product structures, high yield of most target products and the like.

Nickel-Catalyzed Synthesis of Quinazolinediones

A nickel(0)-catalyzed method for the synthesis of quinazolinediones from isatoic anhydrides and isocyanates is described. High-throughput ligand screening revealed that XANTPHOS was the optimal ligand for this transformation. Subsequent optimization studies, supported by kinetic analysis, significantly expanded the reaction scope. The reaction exhibits a case of substrate inhibition kinetics with respect to the isocyanate. Preliminary results on an asymmetric synthesis of atropisomeric quinazolinediones are reported.

Synthesis, molecular structure and spectroscopic studies of some new quinazolin-4(3H)-one derivatives; An account on the N- versus S-Alkylation

A new series of N- and S-alkylated products of 3-aryl-1H,3H-quinazolin-2,4-dione and 3-aryl-2-mercapto-3H-quinazolin-4-one, respectively, were prepared in good yields via efficient nucleophilic substitution reaction of the SH and NH substrates with methyl

Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton

Novel non-steroidal progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton were developed and their structure-activity relationships were investigated. Among the prepared compounds, 4-(4,4-diethyl-3,

Silver(I) ion-mediated desulfurization-cyclization of isothiocyanates with several hydroxy acids and N-substituted amino acids

The title reaction of 2-hydroxy-2-methylpropionic acid with phenyl isothiocyanate gave 5,5-dimethyl-3-phenyl-2,4-oxazolidinedione. The structure was determined by X-Ray crystal analysis, and the reaction pathway was estimated. The reactions of other 2-hyd

Synthesis of 3-Aryl-1H,3H-quinazolin-2,4-diones and Their 2-Thio Analogues

3-Aryl-(2-thio)-1H,3H-quinazolin-2,4-diones (3, R= H, CH3, C2H5; X= O, S) have been obtained by the fusion of isatoic anhydrides (1, R= H, CH3, C2H5) with aryliso(thio)cyanates (2, X= O, S).