1028-37-1

Basic information

• Product Name: 1-methyl-3-phenylquinazoline-2,4(1H,3H)-dione
• Synonyms: 1-Methyl-3-phenyl-2,4(1H,3H)-quinazolinedione; 2,4(1H,3H)-quinazolinedione, 1-methyl-3-phenyl-
• CAS NO: 1028-37-1
• Molecular Formula: C₁₅H₁₂N₂O₂
• Molecular Weight: 252.268
• Mol File: 1028-37-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 407.7°C at 760 mmHg
• Flash Point: 185.6°C
• Density: 1.289g/cm³
• Vapor Pressure: 7.42E-07mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 1-methyl-3-phenylquinazoline-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-3-phenylquinazoline-2,4(1H,3H)-dione(1028-37-1)
• EPA Substance Registry System: 1-methyl-3-phenylquinazoline-2,4(1H,3H)-dione(1028-37-1)

Safety Data

• Hazardous Substances Data: 1028-37-1(Hazardous Substances Data)

Usage

Structure

Quinazoline backbone with a methyl and phenyl group attached

Use

Anti-inflammatory and analgesic agent

Conditions Treated

Rheumatoid arthritis, osteoarthritis, and other inflammatory diseases

Mechanism of Action

Inhibits the production of prostaglandins responsible for pain and inflammation

Clinical Studies

Shown promising results in pain management and inflammation treatment

Potential Development

May be developed into a new and effective medication for pain management and inflammation

Further Research

Needed to fully understand its mechanism of action and potential side effects

Upstream product

• 119-68-6 N-Methylanthranilic acid 
• 5416-30-8 N,N'-diphenyl-S-methyl isothiourea 
• 10328-92-4 N-Methylisatoic anhydride 
• 103-71-9 phenyl isocyanate 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 28831-35-8 (3-phenyl-4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)acetic acid ethyl ester 
• 37029-30-4 N-(3,4-Dihydro-4-oxo-3-phenylquinazolin-2-ylmercaptoacetyl)hydrazine 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 603-23-6 3-phenyl-2,4-(1H,3H)-quinazolinedione 
• 74-88-4 methyl iodide 
• 103-72-0 phenyl isothiocyanate 
• 57266-65-6 3-phenyl-hexahydro-quinazoline-2,4-dione 

Relevant articles and documents

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Method for synthesizing quinazoline-2, 4 (1H, 3H)-diketone compound

The invention discloses a method for synthesizing a quinazoline-2, 4 (1H, 3H)-diketone compound, and belongs to the technical field of synthesis of nitrogen-containing heterocyclic compounds. According to the technical scheme, the method is characterized in that an anthranilic acid compound and an amine compound serve as reaction raw materials, CO serves as a carbonylation reagent, Pd (II) servesas a catalyst, KI or KI/AcOH serves as an additive, Cu (OAc) 2 or O2 or Cu (OAc) 2/O2 serves as an oxidizing agent, and the target product quinazoline-2, 4 (1H, 3H)-diketone compound is prepared through a one-pot multi-component reaction. The method has the advantages of simple and easily available raw material, short synthesis route, high atom economy and step economy, mild reaction conditions, diversified product structures, high yield of most target products and the like.

Synthesis, molecular structure and spectroscopic studies of some new quinazolin-4(3H)-one derivatives; An account on the N- versus S-Alkylation

A new series of N- and S-alkylated products of 3-aryl-1H,3H-quinazolin-2,4-dione and 3-aryl-2-mercapto-3H-quinazolin-4-one, respectively, were prepared in good yields via efficient nucleophilic substitution reaction of the SH and NH substrates with methyl