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(+)-(R)-methyl-(α-naphthyl)phenylsilanol is a chiral organosilicon compound characterized by its unique molecular structure. It consists of a silicon atom bonded to a methyl group, a phenyl group, and an α-naphthyl group, with the latter two being connected to the silicon atom through a hydroxyl group. The compound exhibits optical activity due to its chiral center, which is the carbon atom attached to the silicon and the phenyl group. This chirality is crucial in various applications, such as in the synthesis of pharmaceuticals and agrochemicals, where the spatial arrangement of atoms can significantly influence the compound's biological activity. The compound's specific stereochemistry, indicated by the (+)-(R) notation, further defines its three-dimensional structure, which is essential for understanding its reactivity and potential applications in asymmetric synthesis.

1028-62-2

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1028-62-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1028-62-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,2 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1028-62:
(6*1)+(5*0)+(4*2)+(3*8)+(2*6)+(1*2)=52
52 % 10 = 2
So 1028-62-2 is a valid CAS Registry Number.

1028-62-2Relevant academic research and scientific papers

Highly selective oxidation of organosilanes to silanols with hydrogen peroxide catalyzed by a lacunary polyoxotungstate

Ishimoto, Ryo,Kamata, Keigo,Mizuno, Noritaka

, p. 8900 - 8904 (2009)

Silanol synthesis: Divacant lacunary polyoxotungstate (nBu4N+)4[g- SiW10O34(H2O)2] (I) is an efficient homogeneous catalyst for highly selective oxidation of organosilanes to silanols with 30/60% aqueous H2O2. Various kinds of silanes 1 containing aryl, alkyl, alkenyl, alkynyl and alkoxy groups are chemoselectively converted into the corresponding silanols 2 in high yields with only one equivalent of aqueous H2O2 with respect to the substrate.

O2-enhanced catalytic activity of gold nanoparticles in selective oxidation of hydrosilanes to silanols

Urayama, Teppei,Mitsudome, Takato,Maeno, Zen,Mizugaki, Tomoo,Jitsukawa, Koichiro,Kaneda, Kiyotomi

, p. 1062 - 1064 (2015)

O2 acts as a nonconsumed activator for gold nanoparticles (AuNPs) in the oxidation of hydrosilanes to silanols with water under O2 atmosphere, providing an acceleration of more than 200 times relative to the reaction rate under Ar atmosphere. The AuNP catalyst under aerobic conditions exhibits high activity in the oxidation with high turnover numbers (1230000). Various hydrosilanes including less-reactive bulky ones can be converted to the corresponding silanols in excellent yields. Moreover, the present AuNP catalyst is reusable while maintaining the high performance.

Selective Manganese-Catalyzed Oxidation of Hydrosilanes to Silanols under Neutral Reaction Conditions

Wang, Kaikai,Zhou, Jimei,Jiang, Yuting,Zhang, Miaomiao,Wang, Chao,Xue, Dong,Tang, Weijun,Sun, Huamin,Xiao, Jianliang,Li, Chaoqun

, p. 6380 - 6384 (2019/05/06)

The first manganese-catalyzed oxidation of organosilanes to silanols with H2O2 under neutral reaction conditions has been accomplished. A variety of organosilanes with alkyl, aryl, alknyl, and heterocyclic substituents were tolerated, as well as sterically hindered organosilanes. The oxidation appears to proceed by a concerted process involving a manganese hydroperoxide species. Featuring mild reaction conditions, fast oxidation, and no waste byproducts, the protocol allows a low-cost, eco-benign synthesis of both silanols and silanediols.

THE PREPARATION AND CHEMISTRY OF (R)-(1-NAPHTYL)PHENYLMETHYLSILYLMETHYLLITHIUM: STEREOCHEMISTRY AT SILICON IN THE ELIMINATION OF β-HYDROXYSILANES

Larson, Gerald L.,Prieto, J. Antonio,Ortiz, Edgardo

, p. 3781 - 3790 (2007/10/02)

(R)-(1-naphthyl)phenylmethylsilylmethyllithium has been prepared from 1-naphthylphenylmethylsilylmethyltri-n-butyltin, which is in turn prepared in four steps from (R)-(1-naphthyl)phenylmethylsilane.The title lithium reagent was reacted with benzaldehyde, pivaldehyde, acrolein and 2-methylcyclohexanone to produce the corresponding β-hydroxysilanes in good yield, but with only a 3-4percent diastereomeric excess.Unfortunately, these diastereomers proved impossible to separate.Model studies employing the methyldiphenylsilyl group showed that these β-hydroxysilanes could be protiodesilylated to give the corresponding methyl alcohol.The products from the adduct with pivaldehyde and acrolein were used to investigate the stereochemistry at silicon of the β-hydroxysilanes.This was found to occur with inversion of configuration at silicon when the elimination is carried out with boron fluoride etherate, sulfuric acid or acetic acid/sodium acetate, but with retention of configuration when carried out with potassium hydride.

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