1028-93-9

Usage

Uses

Used in Organic Synthesis:
2-(dimethylamino)ethyl diphenylborinate is used as a catalyst or co-catalyst for facilitating various chemical reactions, primarily focusing on the formation of carbon-carbon bonds and the activation of small molecules. Its high stability and unique reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, 2-(dimethylamino)ethyl diphenylborinate is utilized for its potential to contribute to the development of new synthetic pathways and methodologies. Its unique properties and reactivity are harnessed to explore novel reactions and improve existing synthetic processes.
Used in Material Science:
2-(dimethylamino)ethyl diphenylborinate is also studied for its applications in material science, where its unique characteristics can be leveraged to create new materials with specific properties or to enhance the performance of existing materials. Its role in material science is still under investigation, but its potential is recognized for future advancements in this field.

Upstream product

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 4426-21-5 oxybis(diphenylborane) 

Relevant academic research and scientific papers

2-Aminoethoxydiphenyl borate as a prototype drug for a group of structurally related calcium channel blockers in human platelets

We have synthesized a series of 2-aminoethoxydiphenyl borate (2-APB, 2,2-diphenyl-1,3,2-oxazaborolidine) analogs and tested their ability to inhibit thrombin-induced Ca2+ influx in human platelets. The analogs were either synthesized by adding various substituents to the oxazaborolidine ring (methyl, dimethyl, tert-butyl, phenyl, methyl phenyl, and pyridyl) or increasing the size of the oxazaborolidine ring to seven- and nine-membered rings. NMR analysis of the boron-containing analogs suggests that each of them exist as a ring structure through the formation of an N→B coordinate bond (except for the hexyl analog). The possibility that these boron-containing compounds formed dimers was also considered. All compounds dose-dependently inhibited thrombin-induced Ca2+ influx in human platelets, with the 2,2-diphenyl-1,3,2-oxazaborolidine-5-one derivative having the weakest activity at 100 μM, whereas the (S)-4-benzyl and (R)-4-benzyl derivatives of 2-APB were approximately 10 times more potent than the parent 2-APB. Two nonboron analogs (3-methyl and 3-tert-butyl 2,2-diphenyl-1,3-oxazolidine) were synthesized; they had approximately the same activity as 2-APB, and this implies that the presence of boron was not necessary for inhibitory activity. All of the compounds tested were also able to inhibit thrombininduced calcium release. We concluded that extensive modifications of the oxazaborolidine ring in 2-APB can be made, and Ca2+-blocking activity was maintained. Copyright