1028026-68-7Relevant academic research and scientific papers
A polar radical pair pathway to assemble the pyrimidinone core of the HIV integrase inhibitor raltegravir potassium
Pye, Philip J.,Zhong, Yong-Li,Jones, Gavin O.,Reamer, Robert A.,Houk, Kendall N.,Askin, David
supporting information; experimental part, p. 4134 - 4136 (2009/03/12)
(Chemical Equation Presented) Break up to make up: Combined experimental and computational studies provide evidence that the key step in the synthesis of a novel anti-HIV drug involves an unprecedented stepwise radical pair rearrangement mechanism in which radical fragments are held together by strong electrostatic forces (see scheme); this is favored over alternative mechanisms involving concerted pericyclic rearrangement.
