102808-63-9Relevant academic research and scientific papers
A General, Regiospecific Synthesis of Highly Substituted Quinones
Liebeskind, Lanny S.,Iyer, Suresh,Jewell, Charles F.
, p. 3065 - 3067 (2007/10/02)
A general route to a wide variety of substituted quinones (furyl, indolo, pyrrolo, quinolino, naphtho, and anthra) has been developed via the thermolysis (160 deg C, xylene) and subsequent oxidation (air or Ce4+) of 4-hydroxy-4-substituted-cyclobutenones (eq. 1) and 2-hydroxy-2-substituted-benzocyclobutenones which were formed by the regioselective addition of an appropriate aryl or heteroaryl (etc.) lithium reagent to the correspnding cyclobutenedione.
