1028092-52-5

Basic information

• Product Name: 3-(4-Fluorophenyl)-1H-pyrazole Hcl
• Synonyms: 3-(4-Fluorophenyl)-1H-pyrazole Hcl
• CAS NO: 1028092-52-5
• Molecular Weight: 198.627
• Mol File: 1028092-52-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-Fluorophenyl)-1H-pyrazole Hcl(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Fluorophenyl)-1H-pyrazole Hcl(1028092-52-5)
• EPA Substance Registry System: 3-(4-Fluorophenyl)-1H-pyrazole Hcl(1028092-52-5)

Safety Data

• Hazardous Substances Data: 1028092-52-5(Hazardous Substances Data)

Upstream product

• 1028092-46-7 5-(4-fluorophenyl)-1-(tetrahydropyran-2-yl)-1H-pyrazole 

Relevant articles and documents

A simple, modular method for the synthesis of 3,4,5-trisubstituted pyrazoles

(Chemical Equation Presented) A modular approach for the regiocontrolled preparation of pyrazoles bearing substituents on all three carbon atoms is described. Central to this method is the use of a switchable metal-directing group (MDG) to enable sequential direct lithiation of the 3- and 5-positions of the pyrazole ring. Pyrazole boronic esters obtained from these lithiated intermediates can undergo efficient Suzuki cross-coupling under the developed nonaqueous conditions, which minimize undesirable protolytic deboronation. Halogenation of the 4-position provides the means for substitution at the remaining carbon atom.