1028115-07-2Relevant academic research and scientific papers
A Palladium-Catalyzed Carbonylation Approach to Eight-Membered Lactam Derivatives with Antitumor Activity
Mancuso, Raffaella,Raut, Dnyaneshwar S.,Marino, Nadia,De Luca, Giorgio,Giordano, Cinzia,Catalano, Stefania,Barone, Ines,Andò, Sebastiano,Gabriele, Bartolo
, p. 3053 - 3064 (2016)
The reactivity of 2-(2-alkynylphenoxy)anilines under PdI2/KI-catalyzed oxidative carbonylation conditions has been studied. Although a different reaction pathway could have been operating, N-palladation followed by CO insertion was the favored
Sequence of intramolecular carbonylation and asymmetric hydrogenation reactions: Highly regio- and enantioselective synthesis of medium ring tricyclic lactams
Lu, Shui-Ming,Alper, Howard
, p. 6451 - 6455 (2008/12/22)
The intramolecular cyclocarbonylation reaction with palladium-complexed dendrimers on silica is a very effective method for the regioselective synthesis of methylene 8-, 9-, and 10-membered rings. The heterogeneous dendritic catalysts are easily recovered by simple filtration and reused for up to 10 cycles with only a slight loss of activity. Asymmetric hydrogenation of the resulting unsaturated heterocycles affords optically active tricyclic lactams in excellent yields and in high enantiomeric excess. This process can tolerate a wide array of functional groups, including halide, ether, nitrile, ketone, and ester. Moreover, the variation of heteroatom on the rings does not have any influence on the efficiency and enantioselectivity of the reaction.
