1028203-17-9

Basic information

• Product Name: C₃₃H₂₉FN₂O₄S
• Synonyms: C₃₃H₂₉FN₂O₄S
• CAS NO: 1028203-17-9
• Molecular Weight: 568.669
• Mol File: 1028203-17-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₂₉FN₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₂₉FN₂O₄S(1028203-17-9)
• EPA Substance Registry System: C₃₃H₂₉FN₂O₄S(1028203-17-9)

Safety Data

• Hazardous Substances Data: 1028203-17-9(Hazardous Substances Data)

Upstream product

• 102614-43-7 2-chloro-3-fluoro-5,12-dihydro-5-oxobenzothiazolo<3,2-a>quinoline-6-carboxylic acid 
• 51072-36-7 (+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline 

Relevant articles and documents

Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6 -carboxylic acid

Various 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6 -carboxylic acid derivatives were synthesized from 2-aminothiophenol by a five-step reaction, evaluated for in-vitro and in-vivo antimycobacterial activities against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant Mycobacterium tuberculosis (MDR-TB), and Mycobacterium smegmatis (MC2), and also tested for the ability to inhibit the supercoiling activity of DNA gyrase from M. smegmatis. Among the thirty-four synthesized compounds, 2-(3-(diethylcarbamoyl)piperidin-1-yl)-)-3-fluoro-5,12-dihydro-5-oxobenz othiazolo[3,2-a]quinoline-6-carboxylic acid (7l) was found to be the most active compound in vitro with MIC of 0.18 and 0.08 μM against MTB and MTR-TB, respectively. Compound 7l was found to be 2 and 570 times more potent than isoniazid against MTB and MDR-TB, respectively. In the in-vivo animal model 7l decreased the bacterial load in lung and spleen tissues with 2.78 and 3.12 - log 10 protections, respectively, at the dose of 50 mg/kg body weight.