1028206-56-5

Basic information

• Product Name: XPhos Pd G1
• Synonyms: [2-(2-AMinoethyl)phenyl](chloro)palladiuM-dicyclohexyl(2',4',6'-triisopropyl-2-biphenylyl)phosphine (1:1);Chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) ;XPhos Palladacycle;XPhos precatalyst;XPhos Pd G1;Chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl] palladium(II) methyl-t-butylether adduct;XPhos Pd;Chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl] palladium(II) methyl-t-butylether adduct, min. 98% [XPhos Palladacycle Gen. 1]
• CAS NO: 1028206-56-5
• Molecular Formula: C₄₁H₅₉ClNPPd
• Molecular Weight: 738.76100
• EINECS: 1592732-453-0
• Product Categories: Buchwald Ligands&Precatalysts;Buchwald Precatalysts Series;Pd
• Mol File: 1028206-56-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 205-210°C
• Appearance: white/Powder
• CAS DataBase Reference: XPhos Pd G1(CAS DataBase Reference)
• NIST Chemistry Reference: XPhos Pd G1(1028206-56-5)
• EPA Substance Registry System: XPhos Pd G1(1028206-56-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-52/53
• Safety Statements: 26-61
• WGK Germany: 3
• Hazardous Substances Data: 1028206-56-5(Hazardous Substances Data)

Usage

Reaction

Catalyst for cross-coupling reactions of electron-deficient anilines with aryl chlorides. Catalyst for rapid C-N bond-forming process at low catalyst loading. Catalyst for C-N cross-coupling reactions, at or below room temperature. Catalyst for the synthesis of tetracyclic indoles via intermolecular α-arylation of ketones. Catalyst for the cross-coupling of benzyl chlorides with cyclopropanol-derived ketone homoenolates

Uses

Different sources of media describe the Uses of 1028206-56-5 differently. You can refer to the following data:
1. XPhos Pd G1 is used as androgen receptor modulator for treatment of disorders including prostate cancer.
2. Application Guide for Palladium Catalyzed Cross-Coupling ReactionsCatalyst used for:Amination / cyclization reactionsC-N bond-forming reactions via packed-bed microreactorsBoration of aryl chloridesArylation of oxazoleCross-coupling reactions

General Description

Material may contain up to 5% pentane

Upstream product

• 13078-80-3 2-(2-chlorophenyl)ethanamine 
• 564483-18-7 XPhos 
• 14267-08-4 N,N,N',N'-tetramethylethylenediamine palladium(II) chloride 
• 917-54-4 methyllithium 

Downstream Products

• 936951-63-2 (Cy₂PC₆H₄C₆H₂(iPr)3)Pd 

Relevant articles and documents

A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides

A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally stable, are easily activated under normal reaction conditions at or below room temperature, and ensure the formation of the highly active monoligated Pd(0) complex necessary for oxidative addition. The use of these precatalysts as a convenient source of LPd(0) in C-N cross-coupling reactions is explored. The reactivity that is demonstrated in this study is unprecedented in palladium chemistry. Copyright