1028206-58-7

Basic information

• Product Name: SPhos Pd G1, Methyl t-Butyl Ether Adduct
• Synonyms: Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct, min. 98%;Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) methyl-t-butylether adduct, min. 98% [SPhos Palladacycle];Palladium(II) acetate/2-dicyclohexylphosphino-26dimethoxy-1,1-biphenyl/potassium phosphate admixture [Catkit single-use vials - 1.96 wt% Pd(OAc)2];Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II);Chloro(2-dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl)[2-(2-aMinoethylphenyl)]palladiuM(II) Methyl-t-butylether adduct,98% SPhos Palladacycle;Chloro(2-dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl)[2-(2-aMinoethylphenyl)]palladiuM(II) - Methyl-t-butyl ether adduct;PalladiuM(II) acetate/2-dicyclohexylphosphino-2,6-diMethoxy-1,1'-biphenyl (SPhos)/potassiuM phosphate adMixture [CatKit single-use vials - 1.96 wt% Pd(OAc)2];SPhos Palladacycle
• CAS NO: 1028206-58-7
• Molecular Formula: C₃₄H₄₅ClNO₂PPd
• Molecular Weight: 760.72200
• Product Categories: Buchwald Ligands&Precatalysts;Buchwald Precatalysts Series;Pd
• Mol File: 1028206-58-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 176℃
• Appearance: white/Powder
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: SPhos Pd G1, Methyl t-Butyl Ether Adduct(CAS DataBase Reference)
• NIST Chemistry Reference: SPhos Pd G1, Methyl t-Butyl Ether Adduct(1028206-58-7)
• EPA Substance Registry System: SPhos Pd G1, Methyl t-Butyl Ether Adduct(1028206-58-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1028206-58-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1028206-58-7 differently. You can refer to the following data:
1. Chloro(2-dicyclohexylphosphino-2'',6''-dimethoxy-1,1''-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) has been used as catalyst in, the studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential; ?Biaryl Phosphine Based Pd(II) Amido Complexes: The Effect of Ligand Structure on Reductive Elimination
2. Application Guide for Palladium Catalyzed Cross-Coupling ReactionsCatalyst for C-N bond forming reaction.

Upstream product

• 1323952-86-8 2-phenylethan-1-aminium trifluoromethanesulfonate 
• 1323952-89-1 [Pd₂(C,N-C₆H₄CH₂CH₂NH₂-2)₂(μ-Cl)₂] 
• 1356823-31-8 2-dicyclohexylphosphino-2',6'-dimethoxyphenyl 
• 657408-07-6 dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane 
• 13078-80-3 2-(2-chlorophenyl)ethanamine 
• 14267-08-4 N,N,N',N'-tetramethylethylenediamine palladium(II) chloride 
• 917-54-4 methyllithium 

Downstream Products

• 936951-61-0 (Cy₂PC₆H₄C₆H₃(OMe)2)Pd 

Relevant articles and documents

A new method for high-yield cyclopalladation of primary and secondary amines. Atom-efficient open-to-air inexpensive synthesis of Buchwald-type precatalysts

A new method for high-yield cyclopalladation of primary and secondary amines involving the corresponding ammonium triflates, instead of the amines generally employed, is reported. The method is applied for the synthesis of Buchwald-type precatalysts [Pd(C,N-C6H4CH 2CH(R′)NHR-2)X(phosphine)] that can be easily prepared by reaction of Pd(OAc)2, 1 equiv of the ammonium triflate [PhCH 2CH(R′)NH2R]OTf, and an excess of NaX and then treating the resulting complexes [Pd2(C,N-C6H 4CH2CH(R′)NHR-2)2(μ-X)2] with the appropriate phosphine. This new method has several advantages over Buchwald's reported synthesis.