1028261-11-1Relevant articles and documents
1-arylnaphthalene lignan: A novel scaffold for type 5 phosphodiesterase inhibitor
Ukita, Tatsuzo,Nakamura, Yoshinori,Kubo, Akira,Yamamoto, Yasuo,Takahashi, Masami,Kotera, Jun,Ikeo, Tomohiro
, p. 1293 - 1305 (2007/10/03)
1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan s