1028280-67-2Relevant academic research and scientific papers
Diaryldiamines with dual inhibition of the histamine H3 receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1- phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain
Altenbach, Robert J.,Black, Lawrence A.,Strakhova, Marina I.,Manelli, Arlene M.,Carr, Tracy L.,Marsh, Kennan C.,Wetter, Jill M.,Wensink, Erica J.,Hsieh, Gin C.,Honore, Prisca,Garrison, Tiffany Runyan,Brioni, Jorge D.,Cowart, Marlon D.
supporting information; experimental part, p. 7869 - 7873 (2011/01/12)
A series of compounds was designed as dual inhibitors of the H3 receptor and the norepinephrine transporter. Compound 5 (rNET Ki = 14 nM; rH3R Ki = 37 nM) was found to be efficacious in a rat model of osteoarthritic pain.
Novel synthetic route to fluoxetine
Schulze, Matthias
experimental part, p. 3415 - 3422 (2011/01/12)
Racemic fluoxetine was synthesized from 3-benzoylpropionic acid in five steps in 54% overall yield. Copyright
10-Phenylbutyryl-substituted anthracenones as inhibitors of keratinocyte growth and LTB4 biosynthesis
Mueller, Klaus,Breu, Klaus,Reindl, Hans
, p. 179 - 184 (2007/10/03)
A recent observation that phenylbutyryl anthracenone 2, an analogue of the antipsoriatic anthralin, is a potent inhibitor of leukotriene B4 (LTB4) biosynthesis has prompted a search of other anthracenones with improved antiproliferative activity. In that direction, a limited number of analogues related to 2 have been prepared and evaluated in the HaCaT keratinocytes proliferation and in the polymorphonuclear leukocyte LTB4 assay. The 4-methoxy analogue 2a and the side chain methylated 2l retain the full inhibitory activity of 1 against LTB4 biosynthesis while their antiproliferative activity is markedly enhanced and comparable to that of the antipsoriatic anthralin. In contrast to anthralin, cytotoxic effects against cell membranes are strongly reduced as documented by the LDH activity released from cytoplasm of keratinocytes.
Chemistry, Binding Affinities, and Behavioral Properties of a New Class of "Antineophobic" Mitochondrial DBI Receptor Complex (mDRC) Ligands
Kozikowski, A. P.,Ma, D.,Brewer, James,Sun, S.,Costa, E.,et al.
, p. 2908 - 2920 (2007/10/02)
The mitochondrial DBI receptor complex (mDRC; previously called the peripheral benzodiazepine receptors) is linked to the production of neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate, and others.In order to gain further informa
