1028291-83-9Relevant academic research and scientific papers
The first high-yielding benzyne cyclisation using a phenolic nucleophile: A new route to xanthenes
Knight, David W.,Little, Paul B.
, p. 1141 - 1143 (2007/10/03)
Condensation of dianion 2 derived from aminobenzotriazole 1 with O-benzyl-salicylaldehydes 11 gives intermediate alcohols 12 in good yields. Double hydrogenolysis gives phenols 13 which, upon deprotection and benzyne generation using N-iodosuccinimide, undergo smooth cyclisation to give the iodo-xanthenes 14 in excellent overall yields.
