1028295-08-0Relevant academic research and scientific papers
Design and asymmetric synthesis of β-strand peptidomimetics
Boumendjel, Ahcene,Roberts, John C.,Hu, Essa,Pallai, Peter V.,Rebek Jr., Julius
, p. 4434 - 4438 (1996)
We describe the asymmetric synthesis of non-peptidic compounds that feature rigid backbone conformations and present various side-chain functions. The key step in the synthesis of these compounds is the C-acylation of an appropriate ketone with a suitably protected aspartic acid derivative. The resulting dipeptide modules may be connected to form tetrapeptide mimics. Specifically is described the mimicry of a four-residue segment of CD4, the cellular receptor of HIV-1. The design was based on molecular modeling and the X-ray crystal structures of CD4 and intended to present the most important side chains and backbone elements of the Phe43-Lys46 segment.
