102831-08-3

Usage

Type of compound

Highly reactive chemical compound

Usage

Commonly used in organic synthesis and chemical research

Structure

Ketone derivative with an azido group attached to the first carbon on the butan-2-one chain and a phenyl group on the fourth carbon

Reactivity

Highly explosive and sensitive to heat, shock, or friction

Hazardous nature

Potentially hazardous chemical due to its explosive properties

Applications

Used as a precursor in the synthesis of other organic compounds, with potential applications in the pharmaceutical and materials industries

Safety precautions

Should be handled and stored with extreme caution and under controlled conditions to minimize the risk of explosion or other hazardous incidents.

Upstream product

• 31984-10-8 1-bromo-4-phenylbutan-2-one 
• 20845-80-1 1-chloro-4-phenylbutan-2-one 

Downstream Products

• 31419-53-1 1-amino-4-phenyl-2-butan-one hydrochloride 
• 102831-10-7 1-formamido-4-phenyl-2-butanone 
• 102831-22-1 N-(1-Methyl-2-oxo-4-phenyl-butyl)-formamide 
• 102831-23-2 N-[1-(3-Phenyl-propionyl)-pentyl]-formamide 
• 102831-24-3 N-(1-Benzyl-2-oxo-4-phenyl-butyl)-formamide 
• 102831-13-0 1,5-diphenyl-2-amino-3-pentanone hydrobromide 
• 1083068-77-2 C₁₇H₂₅N₅O₂ 

Relevant academic research and scientific papers

Visible-light-induced N-heterocyclic carbene mediated cascade transformation of N-alkenoxypyridinium salts

While N-alkenoxypyridinium salts are widely used for the synthesis of α-functionalized ketones via umpolung strategy, such approaches are usually limited to special nucleophiles at high temperatures. Herein, we developed an alternative photoinduced N-heterocyclic carbene (NHC)- mediated functionalization of N-alkenoxypyridinium salts with various nucleophiles, including tetramethylammonium azide, secondary amines, aryl and alkyl thiols, and even the challenging C(sp3)-nucleophiles, under mild conditions. A cascade radical-radical coupling/nucleophilic substitution sequence was proposed, wherein the NHC enabled the formation of a photoactive electron donor-acceptor complex for α-iodo ketone synthesis.

Studies on the chemistry and reactivity of α-substituted ketones in isonitrile-based multicomponent reactions

(Chemical Equation Presented) Using the Passerini and Ugi reactions as representative tests, the utility of several α-substituted ketones R-CO-CH2-X (X = sulfonyloxy, acyloxy, azido, halo, hydroxy, and sulfonyl) in isonitrile-based multicompone