102834-67-3

Upstream product

• 64204-39-3 2-Cyano-N-(2,6-dichloro-phenyl)-acetamide 

Downstream Products

• 102818-05-3 6-Methyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide 
• 102818-06-4 5-Methyl-2-thioxo-1,2-dihydro-pyridin-3-carbonsaeure-2,6-dichloro-anilid 
• 102818-13-3 2-(2,6-Dichloro-phenyl)-4,6-dimethyl-isothiazolo[5,4-b]pyridin-3-one 
• 102818-16-6 2-(2,6-Dichloro-phenyl)-6-methyl-isothiazolo[5,4-b]pyridin-3-one 
• 102818-17-7 2-(2,6-Dichloro-phenyl)-5-methyl-isothiazolo[5,4-b]pyridin-3-one 
• 102818-37-1 2-(2,6-Dichloro-phenyl)-isothiazolo[5,4-d]pyrimidin-3-one 
• 102818-00-8 4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carboxylic acid (2,6-dichloro-phenyl)-amide 

Relevant academic research and scientific papers

E-Z-izomerization of 2-methylenethiazolidin-4-ones

The equilibrium concentrations of E- and Z-isomers of thiazolidin-4-ones containing exocyclic double bonds in positions 2 and 5 of the cycle were determined in DMSO-d6. The influence of the nature of the substituents on the equilibrium position was found. Electron-releasing substituents stabilize the E,Z-configuration and electron-withdrawing substituents stabilize the Z,Z-configuration. The association constants of E- and Z-2-ethoxycarbonylmethylenethiazolidin-4-ones with the sodium cation were determined by 1H NMR spectroscopy.

Heterocyclen-Synthesen mit Monothiomalonsaeure-Amiden: Synthese von 3-Oxo-2,3-dihydroisothiazolopyridinen und 3-Oxo-2,3-dihydroisothiazolopyrimidinen

The monothiomalonic acid amides 5, prepared from cyanoacetamides 4 and hydrogen sulphide, react with diketones 6 or aldehyde derivatives 7 to give the 2-thioxo-1,2-dihydropyridine-3-carboxamides 8 which can be cyclised to the 3-oxo-2,3-dihydroisothiazolo