1028342-77-9Relevant academic research and scientific papers
Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis
Axford, Lorraine C.,Simpson, Thomas J.,Willis, Christine L.
, p. 727 - 730 (2007/10/03)
Enzyme essential: Feeding studies with Dreschlera ravenelii show that labeled dihydroisocoumarin 1 is metabolized into monocerin (2) in exceptionally high levels. These results provide evidence for the role of 1 as the first enzyme-free intermediate in the monocerin biosynthesis pathway and, thus, as the final product of the polyketide synthase (PKS) catalyzed part of the pathway. Compound 1 may therefore be of use in further studies to isolate and sequence the monocerin PKS gene.
