102840-81-3Relevant articles and documents
Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature
Pan, Fei,Boursalian, Gregory B.,Ritter, Tobias
, p. 16871 - 16876 (2018)
Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the importance of the difluoromethyl group in medical, agro-, and materials chemistry. A palladium-catalyzed decarbonylative cross-coupling reaction of acid chlorides with a difluoromethyl zinc reagent is achieved to access difluoromethylated compounds. The transformation proceeds at room temperature and shows broad functional group tolerance, thus providing a general and efficient method for decarbonylative difluoromethylation of a wide range of aromatic carboxylic acids.
Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock
Kolarski, Du?an,Miller, Simon,Oshima, Tsuyoshi,Nagai, Yoshiko,Aoki, Yugo,Kobauri, Piermichele,Srivastava, Ashutosh,Sugiyama, Akiko,Amaike, Kazuma,Sato, Ayato,Tama, Florence,Szymanski, Wiktor,Feringa, Ben L.,Itami, Kenichiro,Hirota, Tsuyoshi
supporting information, p. 2078 - 2087 (2021/02/06)
CRY1 and CRY2 proteins are highly conserved components of the circadian clock that controls daily physiological rhythms. Disruption of CRY functions are related to many diseases, including circadian sleep phase disorder. Development of isoform-selective a
Chemoselective deprotonative lithiation of azobenzenes: Reactions and mechanisms
Nguyen, Thi Thanh Thuy,Boussonniere, Anne,Banaszak, Estelle,Castanet, Anne-Sophie,Nguyen, Kim Phi Phung,Mortier, Jacques
, p. 2775 - 2780 (2014/04/17)
Whereas standard strong bases (n-BuLi, s-BuLi/TMEDA, n-BuLi/t-BuOK, TMPMgCl·LiCl, and LDA) reduce the N=N bond of the parent azobenzene (Y = H), aromatic H→Li permutation occurs with LTMP when a suitable director of lithiation (Y = OMe, CONEt2, F) is present in the benzene residue of the azo compound. The method allows direct access to new substituted azobenzenes.
