1028482-01-0Relevant academic research and scientific papers
Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: Bryostatin look-alikes that mimic phorbol ester function
Keck, Gary E.,Kraft, Matthew B.,Truong, Anh P.,Li, Wei,Sanchez, Carina C.,Kedei, Noemi,Lewin, Nancy E.,Blumberg, Peter M.
, p. 6660 - 6661 (2008/12/22)
Highly potent bryostatin analogues which contain the complete bryostatin core structure have been synthesized using a pyran annulation approach as a key strategic element. The A ring pyran was assembled using a pyran annulation reaction between a C1-C8 hydroxy allylsilane and an aldehyde comprising C9-C13. This pyran was transformed to a new hydroxy allylsilane and then coupled with a preformed C ring aldehyde subunit in a second pyran annulation, with concomitant formation of the B ring. This tricyclic intermediate was elaborated to bryostatin analogues which displayed nanomolar to subnanomolar affinity for PKC, but displayed properties indistinguishable from a phorbol ester in a proliferation/attachment assay. Copyright
