102852-71-1

Basic information

• Product Name: 4-methyl-11,11a-dihydro-4H-pyrido[3,2-a]carbazol-11-ium iodide
• CAS NO: 102852-71-1
• Molecular Formula: C₁₆H₁₅IN₂
• Molecular Weight: 362.2082
• Mol File: 102852-71-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 480.7°C at 760 mmHg
• Flash Point: 244.4°C
• Vapor Pressure: 2.12E-09mmHg at 25°C
• CAS DataBase Reference: 4-methyl-11,11a-dihydro-4H-pyrido[3,2-a]carbazol-11-ium iodide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-11,11a-dihydro-4H-pyrido[3,2-a]carbazol-11-ium iodide(102852-71-1)
• EPA Substance Registry System: 4-methyl-11,11a-dihydro-4H-pyrido[3,2-a]carbazol-11-ium iodide(102852-71-1)

Safety Data

• Hazardous Substances Data: 102852-71-1(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 

Relevant articles and documents

Synthesis and evaluation of the tetracyclic ring-system of isocryptolepine and regioiso-mers for antimalarial, antiproliferative and antimicrobial activities

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine 4b to be significantly more active against human prostate cancer (IC50 = 24 nM) than Puromycin (IC50 = 270 nM) and Doxorubicin (IC50 = 830 nM), which are used for clinical treatment. Pyridocarbazoles 9 was also moderately effective against all the employed cancer cell lines and moreover showed excellent biofilm inhibition (9a: MBIC = 100 μM; 9b: MBIC = 100 μM).