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1028527-85-6

(1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1028527-85-6 Structure

  • Basic information

    1. Product Name: (1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine
    2. Synonyms: (1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine
    3. CAS NO:1028527-85-6
    4. Molecular Formula:
    5. Molecular Weight: 407.512
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1028527-85-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: (1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine(1028527-85-6)
    11. EPA Substance Registry System: (1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(4-(methylthio)phenyl)propan-2-amine(1028527-85-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1028527-85-6(Hazardous Substances Data)

1028527-85-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1028527-85-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,8,5,2 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1028527-85:
(9*1)+(8*0)+(7*2)+(6*8)+(5*5)+(4*2)+(3*7)+(2*8)+(1*5)=146
146 % 10 = 6
So 1028527-85-6 is a valid CAS Registry Number.

1028527-85-6Relevant articles and documents

Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators

Hemmerling, Martin,Edman, Karl,Lepist?, Matti,Eriksson, Anders,Ivanova, Svetlana,Dahmén, Jan,Rehwinkel, Hartmut,Berger, Markus,Hendrickx, Ramon,Dearman, Matthew,Jensen, Tina Jellesmark,Wissler, Lisa,Hansson, Thomas

, p. 5741 - 5748 (2016/11/28)

A structure-based design approach led to the identification of a novel class of indazole ether based, non-steroidal glucocorticoid receptor (GR) modulators. Several examples were identified that displayed cell potency in the picomolar range, inhibiting LPS-induced TNF-α release by primary peripheral blood mononuclear cells (PBMCs). Additionally, an improved steroid hormone receptor binding selectivity profile, compared to classical steroidal GR agonists, was demonstrated. The indazole ether core tolerated a broad range of substituents allowing for modulation of the physiochemical parameters. A small sub-set of indazole ethers, with pharmacokinetic properties suitable for oral administration, was investigated in a rat antigen-induced joint inflammation model and demonstrated excellent anti-inflammatory efficacy.

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