1028531-17-0Relevant academic research and scientific papers
Synthesis of stable derivatives of cycloprop-2-ene carboxylic acid
Yan, Ni,Liu, Xiaozhong,Pallerla, Mahesh K.,Fox, Joseph M.
, p. 4283 - 4286 (2008)
(Chemical Equation Presented) Large-scale syntheses of 3-(cycloprop-2-en-1- oyl)oxazolidinones from acetylene and ethyl diazoacetate are described. Unlike other cyclopropenes that bear a single substitutent at C-3, these compounds are stable to long-term storage. Although the cyclopropene derivatives are unusually stable, they are reactive toward cyclic and acyclic dienes in stereoselective Diels-Alder reactions.
TETRAZINE-BASED BIO-ORTHOGONAL COUPLING REAGENTS AND METHODS
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Page/Page column 9; 17, (2009/02/11)
Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and/or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.
