1028634-74-3

Upstream product

• 1028634-77-6 C₂₆H₃₀N₄O₃ 
• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 

Downstream Products

• 1028634-75-4 C₄₄H₅₆N₆O₇ 
• 1028634-78-7 C₃₆H₄₃N₅O₄*ClH 
• 1255196-49-6 C₄₇H₆₂N₆O₇ 

Relevant academic research and scientific papers

Process for the preparation of atazanavir

The invention relates to a process for the preparation of Atazanavir, which comprises reacting the hydrochloride salt of compound (6) with N-methoxycaxbonyl-L-tert-leucine, the removal of the benzyloxycarbonyl group and the reaction with methoxycarbonyl chloride. The process is particularly advantageous in that it allows to use reduced amounts of N-methoxycarbonyl-L-tert-leucine and avoids the use of unstable intermediates.