1028649-08-2Relevant academic research and scientific papers
Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists
Morriello, Gregori J.,DeVita, Robert J.,Mills, Sander G.,Young, Jonathan R.,Lin, Peter,Doss, George,Chicchi, Gary G.,DeMartino, Julie,Kurtz, Marc M.,Tsao, Kwei-Lan C.,Carlson, Emma,Townson, Karen,Wheeldon, Alan,Boyce, Susan,Collinson, Neil,Rupniak, Nadia,Moore, Stephen
, p. 2156 - 2170 (2008/12/21)
Previous work on human NK1 antagonists in which the core of the structure is a substituted pyrrolidine has been disclosed. These compounds showed good binding affinity and functional IP activity, however, many did not exhibit the necessary brai
