102877-52-1Relevant academic research and scientific papers
Synthesis of novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives as nematicidal agents
Chen, Gen-Qiang,Zhu, Li-Na,Yang, Jin-Ming,Zhang, Song,Li, Yuan-Hao,Guo, Xiao-Long,Sun, Di,He, Jia-Xuan,Tian, Yue-E,Liu, Sheng-Ming,Jiang, Jia,Huang, Xiao-Bo,Che, Zhi-Ping
, p. 66 - 75 (2022)
Eighteen novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives were prepared, and their structures well characterized by 1H NMR, HRMS, and mp. Due to the steric hindrance, the substituents on the C = N double bond of all hydrazine compounds (ex
Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties
Yang, Tingting,Shi, Xin,Guo, Libing,Gu, Shaohua,Zhang, Weiwei,Xu, Guiqing,Li, Wei,Jiang, Yuqin
, p. 241 - 247 (2019)
A new series of paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties were synthesized and evaluated for their cytotoxicity in vitro against human non-small cell lung cancer NCI-H1299 cells and human cervical carcinoma HeLa cells. Among them, compared with that of paeonol, compounds 8-acetyl-4-{[(1-(5-chloro-2-nitrophenyl)-1H-1,2,3-triazol-4-yl]methyl}-5-methoxy-2H-1,4-benzoxazin-3(4H)-one, 8-acetyl-4-[(1-mesityl-1H-1,2,3-triazol-4-yl)methyl]-5-methoxy-2H-1,4-benzoxazin-3(4H)-one, and 8-acetyl-5-methoxy-4-{[(1-(naphthalen-1-yl)-1H-1,2,3-triazol-4-yl]methyl}-2H-1,4-benzoxazin-3(4H)-one exhibited significant inhibitory activity toward the human non-small cell lung cancer NCI-H1299 cells (IC50 = 13.36 ± 0.003, 19.75 ± 0.3, 15.79 ± 0.05 μg mL?1). The last compound also exhibited significant inhibitory activity toward the human cervical carcinoma HeLa cells (IC50 = 19.73 ± 1.0 μg mL?1).
Paeonol hydrazone derivative as well as preparation method and application thereof and insecticide
-
Paragraph 0054-0066, (2021/01/29)
The invention relates to a paeonol hydrazone derivative, a preparation method and application thereof, and an insecticide, and belongs to the technical field of botanical pesticides. The paeonol hydrazone derivative has a structure shown as a formula I; in the formula I, X is hydrogen, Y is nitro or X is nitro, Y is hydrogen or X, Y is nitro or X and Y are hydrogen at the same time, and Y is hydrogen at the same time; R1, R2 and R3 are respectively and independently selected from one of hydrogen and R4; and R4 is F, Cl, Br, nitro or alkyl. According to the paeonol hydrazone derivative, the final corrected death rate measured by adopting a small-leaf dish addition method under the concentration of 1mg/mL can reach 40% or above and can reach 70% or above to the maximum, the effect of preventing and treating the grassland spodoptera litura is remarkable, and the paeonol hydrazone derivative can be used as a new drug variety for preparing botanical insecticides.
Paeonol acylhydrazone derivative, preparation method and application thereof and insecticide
-
Paragraph 0057-0070, (2021/02/06)
The invention relates to a paeonol acylhydrazone derivative, a preparation method and application thereof and an insecticide, and belongs to the technical field of insecticides. The paeonol acylhydrazone derivative has a structure shown as a formula I, in
Paeonol benzoxazine compound with anti-tumor activity as well as preparation method and application of paeonol benzoxazine compound
-
Paragraph 0042-0046, (2019/06/07)
The invention discloses a paeonol benzoxazine compound with anti-tumor activity as well as a preparation method and an application of the paeonol benzoxazine compound, and belongs to the technical field of synthesis of anti-tumor drugs. The technical scheme is characterized in that the paeonol benzoxazine compound with anti-tumor activity has the following structural formula in the description. The invention also discloses the preparation method and the application of the compound. The synthesis process is simple, easy to operate and low in cost, and also has the characteristic of low pollution; the synthesized compound can inhibit growth of human non-small cell lung cancer cells NCI-H1299 and human cervical carcinoma HeLa cells, thereby playing a significant role in promoting human research on treatment of lung adenocarcinoma and cervical cancer, and having broad application prospect in the field of medicine.
