102879-33-4

Usage

Uses

Used in Pharmaceutical Industry:
3(2H)-Isoquinolinone,5,6,7,8-tetrahydro-(9CI) is used as a key intermediate in the synthesis of various medicinal compounds for its potential biological activities. It contributes to the development of new drugs by facilitating chemical reactions that produce therapeutically relevant molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 3(2H)-Isoquinolinone,5,6,7,8-tetrahydro-(9CI) serves as a precursor in the production of agrochemicals, leveraging its potential biological activities to create compounds that can be used in pest control and crop protection.
Used in Antioxidant Applications:
3(2H)-Isoquinolinone,5,6,7,8-tetrahydro-(9CI) is utilized as an antioxidant in various applications, including the preservation of food products and the development of pharmaceuticals, due to its ability to neutralize harmful free radicals and prevent oxidative damage.
Used in Antimicrobial Applications:
3(2H)-Isoquinolinone,5,6,7,8-tetrahydro-(9CI) is employed as an antimicrobial agent in both medical and agricultural settings, where it helps combat microbial infections and contributes to the development of antimicrobial products, thanks to its inherent antimicrobial properties.

Upstream product

• 102236-82-8 3-hydroxy-5,6,7,8-tetrahydro-isoquinoline-4-carboxylic acid 
• 7651-81-2 3-isoquinolinol 
• 17507-05-0 1-phenyl-1,4-dihydro-3(2H)-isoquinolinone 
• 53661-31-7 3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile 
• 7651-81-2 3-Hydroxyisoquinoline 
• 105340-73-6 3-hydroxy-5,6,7,8-tetrahydro-isoquinoline-4-carboxylic acid ethyl ester 
• 53661-31-7 3-hydroxy-5,6,7,8-tetrahydro-isoquinoline-4-carbonitrile 

Downstream Products

• 34784-02-6 3-bromoisoquinoline 
• 53987-60-3 1,3-dibromoisoquinoline 
• 36556-06-6 5,6,7,8-tetrahydroisoquinoline 
• 1105662-39-2 3-chloro-7,8-dihydroisoquinolin-5(6H)-one 

Relevant academic research and scientific papers

Synthesis and Cytoxicity of Sempervirine and Analogues

Sempervirine and analogues were synthesized using a route featuring Sonogashira and Larock Pd-catalyzed reactions. Structure-activity relationships were investigated using three human cancer cell lines. 10-Fluorosempervirine is the most potently cytotoxic member of the family yet described.

Superacidic activation of 1- and 3-isoquinolinols and their electrophilic reactions

Isomeric 1- and 3-isoquinolinols (11 and 12) when activated in CF3SO3H-SbF5 acid system undergo selective ionic hydrogenation with cyclohexane to give 5,6,7,8-tetrahydro-1(2H)- and 5,6,7,8-tetrahydro-3(2H)-isoquinolinones (22 and 27). Under the influence of aluminum chloride similar products were also obtained along with 3,4-dihydro-1(2H)- and 1,4-dihydro-3(2H)-isoquinolinones (23 and 28), respectively. Compounds 11 and 12 also condense with benzene in the presence of aluminum halides, under mild conditions, to give 3,4-dihydro-3-phenyl-1(2H)- and 1,4-dihydro-1-phenyl-3(2H)-isoquinolinones (24 and 29), respectively. Prolonged reaction time or catalysis under strongly acidic HBr-AlBr3 provides an alternative reaction pathway to yield 5,6-dihydro-6,8-diphenyl-1(2H)- and 5,6,7,8-tetrahydro-6,8-diphenyl-3(2H)-isoquinolinones (25 and 30), respectively. Products 24 and 29 were also found to revert back to 11 and 12 in the presence of aluminum halides in o-dichlorobenzene. The mechanism of these intriguing reactions, which involves superelectrophilic dicationic intermediates, is discussed.

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS

Selective, non-peptide antagonists of the ma opioid receptor { MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction.

ACETALS OF LACTAMS AND ACID AMIDES. 55. STUDY OF REACTION OF 3-OXOPYRIDINE AND ISOQUINOLIN-3-ONE DERIVATIVES WITH DIMETHYLFORMAMIDE DIETHYL ACETAL

The reactions of 4-carbamoyl- and 4-cyanopyridin-3-one and 4-cyanoisoquinolin-3-one with DMFA diethyl acetal were studied, and hydrogenated di- and trimethylene derivatives of 2,7-naphthyridine-1,8-dione were synthesized.It was found that O- or N-alkylation reactions of the pyridone fragment of the starting bicyclic compounds take place together with the condensation of the DMFA acetal at the amide amino group or the active methylene unit.