1028800-95-4Relevant academic research and scientific papers
Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus
Wang, Alan Xiangdong,Chen, Jie,Zhao, Qian,Sun, Li-Qiang,Friborg, Jacques,Yu, Fei,Hernandez, Dennis,Good, Andrew C.,Klei, Herbert E.,Rajamani, Ramkumar,Mosure, Kathy,Knipe, Jay O.,Li, Danshi,Zhu, Jialong,Levesque, Paul C.,McPhee, Fiona,Meanwell, Nicholas A.,Scola, Paul M.
, p. 590 - 596 (2017)
The design and synthesis of a series of tripeptide acylsulfonamides as potent inhibitors of the HCV NS3/4A serine protease is described. These analogues house a C4 aryl, C4 hydroxy-proline at the S2 position of the tripeptide scaffold. Information relatin
