1028826-13-2Relevant academic research and scientific papers
Acid-catalyzed synthesis of 10-substituted triazolyl artemisinins and their growth inhibitory activity against various cancer cells
Oh, Sangtae,Shin, Woon-Seob,Ham, Jungyeob,Lee, Seokjoon
, p. 4112 - 4115 (2010)
A diastereomeric and regioisomeric library of 10-substituted triazolyl artemisinin compounds (6a-6h, 7a-7h, and 8a-8h) with a potent growth inhibitory activities against various cancer cell lines was established. These compounds were synthesized by a reaction with dihydroartemisinin (2) and various substituted triazoles (5a-5h) in methylene chloride using a BF3Et2O catalyst. Most of the compounds exhibited a strong potency in the submicromolar range, and, in particular, 6f, 7f, and 8f, which have a pentylphenyltriazole moiety, proved to be promising candidates for preclinical trials.
Bitriazolyl acyclonucleosides with antiviral activity against tobacco mosaic virus
Li, Wei,Xia, Yi,Fan, Zhijin,Qu, Fanqi,Wu, Qiongyou,Peng, Ling
, p. 2804 - 2809 (2008/09/19)
Bitriazolyl acyclonucleosides were synthesized via the Huisgen reaction and then subjected to ammonolysis. The antiviral activity of these nucleosides against tobacco mosaic virus (TMV) was assessed. Like the previously described bitriazolyl compounds, th
