1028832-41-8Relevant academic research and scientific papers
An efficient 1,2,4-triazine-based route to the louisianin alkaloids
Catozzi, Nicola,Wasnaire, Pierre,Taylor, Richard J.K.
, p. 2865 - 2868 (2008)
A new, short and efficient route to louisianins C and D is described in which the pyridine ring is constructed from a disubstituted 1,2,4-triazine by an inverse-electron-demand Diels-Alder/retro-Diels-Alder/aromatisation cascade sequence. This eight-step
Synthesis of the louisianin alkaloid family via a 1,2,4-triazine inverse-electron-demand Diels-Alder approach
Catozzi, Nicola,Edwards, Michael G.,Raw, Steven A.,Wasnaire, Pierre,Taylor, Richard J. K.
supporting information; experimental part, p. 8343 - 8354 (2010/02/17)
Chemical Equation Presented) Isolated in 1995, the four members of the louisianin family (A, B, C and D) are simple pyridine and 2-pyridone alkaloids that display both antibacterial and anticancer activity. Herein we describe the synthesis of all four members of the louisianin family, from a conveniently prepared 1,2,4-triazine and via a common tetrasubstituted pyridine intermediate. This study includes the synthesis of louisianin B in both racemic form and as the (-)-enantiomer. 2009 American Chemical Society.
