1028841-76-0Relevant academic research and scientific papers
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Edmondson, Scott D.,Wei, Lan,Xu, Jinyou,Shang, Jackie,Xu, Shiyao,Pang, Jianmei,Chaudhary, Ashok,Dean, Dennis C.,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Patel, Reshma A.,Patel, Sangita B.,Scapin, Giovanna,Wu, Joseph K.,Beconi, Maria G.,Thornberry, Nancy A.,Weber, Ann E.
, p. 2409 - 2413 (2008)
The synthesis, selectivity, rat pharmacokinetic profile, and drug metabolism profiles of a series of potent fluoroolefin-derived DPP-4 inhibitors (4) are reported. A radiolabeled fluoroolefin 33 was shown to possess a high propensity to form reactive metabolites, thus revealing a potential liability for this class of DPP-4 inhibitors.
