10289-32-4Relevant academic research and scientific papers
Electrophilic α-formylation of carbonyl compounds using norephedrine-derived 2-metohoxy oxazolidines. A novel asymmetric formation of quaternary stereocenters
Palazzi, Camillo,Poli, Giovanni,Scolastico, Carlo,Villa, Roberto
, p. 4223 - 4226 (1990)
The BF3·Et2O promoted addition of enamines and silylenolethers, to the nor-ephedrine-derived orthoamides 1 or 5 has been studied. A judicious choice of the type of nucleophile and electrophile leads to useful selectivities. When a quaternary α-carbonyl stereocenter is created, the direct removal of the chiral auxiliary is possible and renders the overall process an efficient asymmetric carbonyl α-formylation.
