1029-09-0Relevant academic research and scientific papers
Decarboxylative C-H alkylation of heteroarene N-oxides by visible light/copper catalysis
Liu, Duan-Yang,Liu, Xu,Gao, Yan,Wang, Chao-Qun,Tian, Jie-Sheng,Loh, Teck-Peng
, p. 8978 - 8983 (2020)
This paper reports a highly site-selective alkylation of heteroarene N-oxides using hypervalent iodine(III) carboxylates to serve as an alkylating agent in the presence of a cheap copper catalyst under visible light conditions. This mild method proceeds at room temperature in an air atmosphere and can withstand various heteroarene N-oxides as well as various primary, secondary, and tertiary alkyl carboxylic acids. It also provides a practical method for enabling the rapid conversion of commercially available raw materials into medically relevant “drug-like” molecules.
