1029062-38-1Relevant academic research and scientific papers
Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles
Alp, Ayse Selen,Kilcigil, Gülgün,?zdamar, Elin Deniz,oban, Tülay,Eke, Binay
, p. 42 - 53 (2015/02/19)
Some novel 2-(substitutedbenzylthio)-5-((2-(4-substitutedphenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles (5-12) and 2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N′-(arylmethylene)acetohydrazide derivatives (13-22) were prepared and their in
Design and one-pot and microwave-assisted synthesis of 2-amino/5-aryl-1,3, 4-oxadiazoles bearing a benzimidazole moiety as antioxidants
Kerimov, Aegar,Ayhan-Kaelcaegil, Guelguen,Oezdamar, Elcin Deniz,Can-Eke, Benay,Coban, Tuelay,Oezbey, Sueheyla,Kazak, Canan
scheme or table, p. 549 - 556 (2012/08/14)
In this study, two new series of 2-amino-1,3,4-oxadiazoles and 5-aryl-1,3,4-oxadiazoles carrying a benzimidazole moiety were synthesized. The antioxidant properties of these compounds were investigated in vitro by the determination of the microsomal NADPH-dependent inhibition of lipid peroxidation levels (LP), the microsomal ethoxyresorufin O-deethylase activity (EROD), and DPPH radical scavenger effects. Among the tested compounds, 2-[(2-(4- chlorophenyl)-1H-benzo[d]imidazole-1-yl)methyl]-5-(4-fluorophenyl)-1,3, 4-oxadiazole (9) was found to be the most active compound in all three in vitro systems. Two new series of 2-amino-1,3,4-oxadiazoles and 5-aryl-1,3,4- oxadiazoles carrying a benzimidazole moiety were synthesized and their antioxidant properties were investigated in vitro. 2-[(2-(4-Chlorophenyl)-1H- benzo[d]imidazole-1-yl)methyl]-5-(4-fluorophenyl)-1,3,4-oxadiazole (9) was found to be the most active compound in all three in vitro systems. Copyright
Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class
Kus, Canan,Ayhan-Kilcigil, Guelguen,Oezbey, Sueheyla,Kaynak, F. Betuel,Kaya, Melek,Coban, Tuelay,Can-Eke, Benay
, p. 4294 - 4303 (2008/09/20)
Some novel 1-methyl-4-(2-(2-substitutedphenyl-1H-benzimidazol-1-yl)acetyl)thiosemicarbazides (16a-20a), 5-[(2-(substitutedphenyl)-1H-benzimidazol-1-yl)methyl]-N-methyl-1,3,4-thiadiazol-2-amines (17b-20b), and 5-[(2-(substitutedphenyl)-1H-benzimidazol-1-yl)methyl-4-methyl-2H-1,2,4-triazole-3(4H)-thiones (16c-20c) were synthesized and tested for antioxidant properties by using various in vitro systems. Compounds 16a-20a were found to be a good scavenger of DPPH radical (IC50, 26 μM; IC50, 30 μM; IC50, 43 μM; IC50, 55 μM; IC50, 74 μM, respectively) when compared to BHT (IC50, 54 μM). Noteworthy results could not be found on superoxide radical. Compound 19b, which is the most active derivative inhibited slightly lipid peroxidation (28%) at 10-3 M concentration. Compound 17c inhibited the microsomal ethoxyresorufin O-deethylase (EROD) activity with an IC50 = 4.5 × 10-4 M which is similarly better than the specific inhibitor caffeine IC50 = 5.2 × 10-4 M.
