1029092-34-9Relevant academic research and scientific papers
Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines
Dwivedi, Atma P.,Kumar, Shailesh,Varshney, Vandana,Singh, Amar B.,Srivastava, Arvind K.,Sahu, Devi P.
, p. 2301 - 2305 (2008)
A series of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines were synthesized and evaluated for their antihyperglycemic activity. Compounds 3g and 6d exhibited lowering of postprandial plasma glucose by 30.7%, 23.3% in SLM and 25.6%, 25.4% in STZ models respectively which is significant compared to metformin and glybenclamide. Other compounds exhibited moderate to good activity ranging from 19.5% to 32.8% in SLM and 3.26% to 25.4% in STZ models.
