1029101-24-3Relevant academic research and scientific papers
Novel piperonal 1,3,4-thiadiazolium-2-phenylamines mesoionic derivatives: Synthesis, tyrosinase inhibition evaluation and HSA binding study
Lopes, Natália Drumond,Chaves, Otávio Augusto,de Oliveira, Márcia C.C.,Sant'Anna, Carlos Mauricio R.,Sousa-Pereira, Danilo,Netto-Ferreira, José Carlos,Echevarria, Aurea
, p. 1062 - 1072 (2018)
A novel series of piperonal mesoionic derivatives (PMI 1–6) was synthesized. Tyrosinase inhibition in the presence of PMI-1, ?2, ?3, ?4, ?5 and ?6 as well as human serum albumin (HSA) binding studies with PMI-5 and PMI-6 were done by spectroscopic and the
Improved synthesis of 1,3,4-thiadiazolium-2-phenylamines using microwave and ultrasound irradiation and investigation of their cytotoxic activity
Dos Reis, Camilla Moretto,Echevarria-Lima, Juliana,Miranda, Amanda Fraga,Echevarria, Aurea
scheme or table, p. 1505 - 1510 (2011/10/19)
Uma nova e eficiente si?ntese de oito derivados da classe 1,3,4-tiadiazolio-2-fenilaminas (1-8, sendo o derivado 8 ine?dito na literatura) foi realizada utilizando cloreto de tionila ou cloreto de trimetilsilano como catalisadores sob irradiac?a?o de micr
Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies
da Silva Ferreira, Welisson,Freire-de-Lima, Leonardo,Saraiva, Victor Barbosa,Alisson-Silva, Frederico,Mendonca-Previato, Lucia,Previato, Jose Osvaldo,Echevarria, Aurea,de Lima, Marco Edilson Freire
, p. 2984 - 2991 (2008/09/19)
We herein describe the synthesis and characterization of nine new 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine. We evaluate their toxic effects against the different evolutive forms of Trypanosoma cruzi, and the host cell (murine macrophages). The results obtained show that mesoionic hydrochloride MI possesses the best activity profile. Compound MI may be a prototype for use in the development of a new chemotherapeutic agent with high efficiency, which may be employed in the treatment of Chagas' disease.
