1029127-63-6Relevant articles and documents
Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
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, (2015/09/23)
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.
Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents
Chong, Hyun-Soon,Song, Hyun A.,Ma, Xiang,Lim, Sooyoun,Sun, Xiang,Mhaske, Santosh B.
scheme or table, p. 3011 - 3013 (2009/12/01)
Bile acid-polyaminocarboxylate conjugates containing NE3TA, a potential iron chelator displayed significant cytotoxicities in both HeLa and HT29 colon cancer cells, and cholic acid-NE3TA attached to an organic fluorophore was shown to enter the HT29 cance
A novel cholic acid-based contrast enhancement agent for targeted MRI
Chong, Hyun-Soon,Song, Hyun A.,Lim, Sooyoun,Macrenaris, Keith,Ma, Xiang,Lee, Haisung,Bui, Phuong,Meade, Thomas
, p. 2505 - 2508 (2008/09/21)
The novel Gd(III) complexes of heptadentate ligands NE3TA and NE3TA-Bn were prepared, and their relaxivities were measured and favorably compared to the commercially available MRI contrast enhancement agent Gd(DOTA). NE3TA was conjugated with cholic acid (CA) to produce CA-NE3TA. TEM images of Gd(CA-NE3TA) indicate that the complex self-assembles forming nano-sized micelles and displays an over threefold increased relaxivity compared to Gd(DOTA). The new cholic acid-conjugated nanoparticle MR contrast enhancement agent, Gd(CA-NE3TA) possesses great promise for use in targeted MRI.