102916-91-6

Upstream product

• 65295-61-6 3-(4-fluorophenyloxy)-benzaldehyde 
• 143621-71-0 (S)-(+)-1-cyano-1-<3-(4-fluorophenoxy)phenyl>methyl acetate 

Downstream Products

• 65295-53-6 (1R,3R)-2,2-Dimethyl-3-(2-methyl-propenyl)-cyclopropanecarboxylic acid (S)-cyano-[3-(4-fluoro-phenoxy)-phenyl]-methyl ester 
• 65295-53-6 (1R,3R)-2,2-Dimethyl-3-(2-methyl-propenyl)-cyclopropanecarboxylic acid (R)-cyano-[3-(4-fluoro-phenoxy)-phenyl]-methyl ester 
• 65295-53-6 (1S,3R)-2,2-Dimethyl-3-(2-methyl-propenyl)-cyclopropanecarboxylic acid (R)-cyano-[3-(4-fluoro-phenoxy)-phenyl]-methyl ester 
• 65295-53-6 (1S,3R)-2,2-Dimethyl-3-(2-methyl-propenyl)-cyclopropanecarboxylic acid (S)-cyano-[3-(4-fluoro-phenoxy)-phenyl]-methyl ester 

Relevant academic research and scientific papers

One-Pot Synthesis of Optically Active Cyanohydrin Acetates from Aldehydes via Lipase-Catalyzed Kinetic Resolution Coupled with in Situ Formation and Racemization of Cyanohydrins

A novel one-pot synthesis of optically active cyanohydrin acetates from aldehydes has been accomplished by lipase-catalyzed kinetic resolution coupled with in situ formation and racemization of cyanohydrins in an organic solvent.Racemic cyanohydrins 2, generated from aldehydes 1 and acetone cyanohydrin in diisopropyl ether under the catalysis of basic anion-exchange resin (OH- form), were acetylated stereoselectively by a lipase from Pseudomonas cepacia (Amano) with isopropenyl acetate as an acylating reagent.The (S)-isomer of 2 was preferentially acetylated by the lipase, while the unreacted (R)-isomer was continuously racemized through reversible transhydrocyanation catalyzed by the resin.These processes thus enabled one stage conversion of various aldehydes 1a-n into the corresponding (S)-cyanohydrin acetates 3a-n with up to 94 percent ee in 63-100 percent conversion yields.The racemization of the optically active cyanohydrin 2e by Amberlite IRA-904 (OH- form) was found to be much faster then the enzymatic acetylation, confirming the effective second-order asymmetric transformation.Enzymatic deacetylation of (S)-cyanohydrin acetates in an organic solvent and the synthesis of optically active pyrethroids are also described.

Cyanohydrination catalyst comprising non-crystalline or amorphous dipeptide

A cyanohydrination catalyst for the preparation of alphahydroxynitriles from aldehydes and ketones comprises a solid cyclo(D-phenylalanyl-D-histidine) dipeptide having a non-crystalline or amorphous component.