1029220-83-4Relevant academic research and scientific papers
Condensation of γ-bromodypnone with thiocarbamides: Synthesis of 4,4-disubstituted 4,5-dihydro-1,3-thiazol-2-amines and thiazolidin-2-ones
Potikha,Turov,Kovtunenko
, p. 86 - 91 (2008/12/21)
The reaction of 4-bromo-1,3-diphenyl-2-buten-1-one with thiourea or N,N′-diphenylthiourea gives 2-(2-amino-4-phenyl-4,5-dihydro-1,3-thiazol-4- yl)-and 2-[3,4-diphenyl-2-(phenylimino)-1,3-thiazolidin-4-yl]-1-phenyl-1- ethanone - the products of nucleophilic substitution of the halogen atom and Michael addition at position 3 of the 2-buten-1-one system. A similar reaction with thiosemicarbazide and 1-phenylthiosemicarbazide gives the 4-(2-oxo-2-phenylethyl)-4-phenyl-and 4-(2-oxo-2-phenylethyl)-3,4-diphenyl-1,3- thiazolidin-2-one hydrobromides respectively.
