10293-98-8

Basic information

• Product Name: 1-Chlorohex-5-en-2-ol
• Synonyms: 1-Chlorohex-5-en-2-ol
• CAS NO: 10293-98-8
• Molecular Formula: C₆H₁₁ClO
• Molecular Weight: 134.60394
• Mol File: 10293-98-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chlorohex-5-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chlorohex-5-en-2-ol(10293-98-8)
• EPA Substance Registry System: 1-Chlorohex-5-en-2-ol(10293-98-8)

Safety Data

• Hazardous Substances Data: 10293-98-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Production:
1-Chlorohex-5-en-2-ol is used as a key intermediate in the synthesis of various pharmaceuticals. Its chemical structure allows it to be a versatile building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used as a Solvent in Cleaning Products:
In the cleaning industry, 1-Chlorohex-5-en-2-ol serves as an effective solvent. Its ability to dissolve a wide range of substances makes it suitable for use in cleaning products, enhancing their cleaning power and efficiency.
Used in Organic Synthesis:
1-Chlorohex-5-en-2-ol is utilized as an intermediate in organic synthesis, playing a crucial role in the production of various chemical compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used as a Precursor in Insecticide and Herbicide Synthesis:
In the agricultural sector, 1-Chlorohex-5-en-2-ol is employed as a precursor in the synthesis of insecticides and herbicides. Its chemical properties enable the development of effective pest control agents, helping to protect crops and maintain agricultural productivity.
However, it is important to note that 1-Chlorohex-5-en-2-ol is considered a hazardous substance. It may cause irritation to the skin, eyes, and respiratory system, and can be harmful if ingested or inhaled in large quantities. Therefore, proper handling, storage, and safety precautions are essential when working with this chemical compound.

Upstream product

• 10353-53-4 1,2-epoxy-5-hexene 
• 2622-05-1 allylmagnesium bromide 
• 106-89-8 epichlorohydrin 
• 106-95-6 allyl bromide 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 10353-53-4 1,2-epoxy-5-hexene 

Relevant articles and documents

Intramolecular cyclopropanation of epichlorohydrin-derived unsaturated chlorohydrins

Concise stereoselective syntheses of bicyclo[3.1.0]hexan-2-ols and a bicyclo[4.1.0]heptan-2-ol are achieved via regioselective ring-opening of epichlorohydrin with allylic and homoallylic Grignard reagents, followed by lithium 2,2,6,6-tetramethylpiperidide-induced intramolecular cyclopropanation of the resulting unsaturated chlorohydrins. Georg Thieme Verlag Stuttgart.

A novel gallium/samarium-mediated coupling of epoxides with allyl halides in aqueous media and synthesis of homoallylic alcohols

A mild and efficient protocol for the coupling of various substituted epoxides 1 with allylgallium reagent generated in situ in a Bu 4NBr-DMF-H2O system have been developed. The coupling is also found to be equally effective when samarium is used in lieu of gallium and the corresponding homoallylic alcohols 2 were obtained in almost comparable yields. Copyright

Lewis Acid Promoted Ring-Opening Allylation of Epichlorohydrin with Allylic Silanes and Stannanes To Afford 1-Chloro-5-alken-2-ols. A Short Synthesis of (S)-(-)-Ipsenol

Epichlorohydrine (1) was allylated in good yields with representative allylic silanes (2, 5, 7, 9) and stannanes (12, 18) in the presence of appropriate Lewis acids.The reaction proceeds with ring opening at the unsubstituted site in 1 and with allylic inversion in the allylating agents to give 1-chloro-5-alken-2-ols cleanly.A short synthesis of (S)-(-)-ipsenol (29) from 1 and an (allenylmethyl)silane (26) demonstrates the utility of this method in organic synthesis.

An easy procedure for the highly regioselective conversion of epoxides to halohydrins

Several epoxides and epoxy alcohols have been opened to the corresponding halohydrins by lithium halides with Amberlyst in CH3CN at room temperature: the reaction proceeds in quantitative yields with high degree of regioselectivity.

Chemo and regioselective opening of ethereal carbon-oxygen bonds by monochloroborane-dimethylsulfide

Monochloroborane-dimethylsulfide 1 is a mild chemo and regioselective reagent useful in the opening of epoxides, THP ethers, ketals and ethers.