1029431-37-5

Basic information

• Product Name: C₂₈H₃₁F₄N₅O₂S
• CAS NO: 1029431-37-5
• Molecular Weight: 577.646
• Mol File: 1029431-37-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₁F₄N₅O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₁F₄N₅O₂S(1029431-37-5)
• EPA Substance Registry System: C₂₈H₃₁F₄N₅O₂S(1029431-37-5)

Safety Data

• Hazardous Substances Data: 1029431-37-5(Hazardous Substances Data)

Upstream product

• 1029431-29-5 C₁₅H₁₈N₂S 
• 1029431-47-7 C₁₃H₁₃F₄N₃O₂ 
• 769-39-1 2,3,5,6-tetraflourophenol 

Relevant articles and documents

Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease

Inhibition of the cysteine protease cruzain from Trypanosoma cruzi has been studied pre-clinically as a new chemotherapeutic approach to treat Chagas' disease. Efficacious effects of vinylsulfone-based cruzain inhibitors in animal models support this therapeutic hypothesis. More recently, substrate-activity screening was used to identify nonpeptidic tetrafluorophenoxymethyl ketone inhibitors of cruzain that showed promising efficacy in animal models. Herein we report efforts to further optimize the in vitro potency and in vivo pharmacokinetic properties of this new class of cruzain inhibitors. Through modifications of the P1, P2 and/or P3 positions, new analogs have been identified with reduced lipophilicity, enhanced potency, and improved oral exposure and bioavailability.