1029434-20-5Relevant academic research and scientific papers
Novel substituted aminoalkylguanidines as potential antihyperglycemic and food intake-reducing agents
Tassoni, Emanuela,Giannessi, Fabio,Brunetti, Tiziana,Pessotto, Pompeo,Renzulli, Michela,Travagli, Massimiliano,Rajam?ki, Suvi,Prati, Samanta,Dottori, Secondo,Corelli, Federico,Cabri, Walter,Carminati, Paolo,Botta, Maurizio
supporting information; experimental part, p. 3073 - 3076 (2009/04/06)
We report the synthesis and evaluation of aminoalkylguanidine analogues and derivatives in C57BL/KsJ db/db diabetic mice, following identification by random screening of 1a and 1b as potential antihyperglycemics and/or modulators of food intake. These compounds are related to galegine, a γ,γ- dimethylallylguanidine. Between the newly identified compounds, 1h N-(cyclopropylmethyl)-N′-(4-(aminomethyl)-cyclohexylmethyl)guanidine showed the most balanced activity as antihyperglycemic and food intake-reducing agent.
