1029491-99-3

Basic information

• Product Name: C₁₈H₈Cl₃N₅S
• CAS NO: 1029491-99-3
• Molecular Weight: 432.72
• Mol File: 1029491-99-3.mol

Chemical Properties

• CAS DataBase Reference: C₁₈H₈Cl₃N₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₈Cl₃N₅S(1029491-99-3)
• EPA Substance Registry System: C₁₈H₈Cl₃N₅S(1029491-99-3)

Safety Data

• Hazardous Substances Data: 1029491-99-3(Hazardous Substances Data)

Upstream product

• 27810-64-6 isoquinoline-5-carboxylic acid 
• 1029491-80-2 4-amino-5-(2,3,5-trichlorophenyl)-4H-[1,2,4]triazole-3-thiol 

Relevant articles and documents

Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety

The reaction of 2,3,5-trichlorobenzoic acid hydrazide with carbon disulfide and potassium hydroxide followed by treatment with hydrazine hydrate afforded 3-(2,3,5-trichlorophenyl)-4-amino-1,2,4-triazole-5-thione (6). Alternatively, this triazole was also synthesized by fusing 2,3,5-trichlorobenzoic acid with thiocarbohydrazide. Condensation of (6) with various aromatic carboxylic acids in the presence of phosphorous oxychloride or with phenacyl bromides afforded two series of fused heterocycles namely 6-(substituted aryl)-3-(2,3,5-trichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadizoles (7) and 6-(substituted aryl)-3-(2,3,5-trichlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiaz ines (8), respectively. The structures of these newly synthesized compounds are characterised by elemental analysis, IR, 1H NMR and mass spectroscopic studies. All the synthesized compounds were screened for their antimicrobial and anti-inflammatory activities. Some of the compounds exhibited promising antimicrobial and anti-inflammatory activities.