1029542-48-0

Basic information

• Product Name: 2-(4-bromophenyl)-N-cyclohexyl-2-oxoacetamide
• Synonyms: 2-(4-bromophenyl)-N-cyclohexyl-2-oxoacetamide
• CAS NO: 1029542-48-0
• Molecular Weight: 310.191
• Mol File: 1029542-48-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)-N-cyclohexyl-2-oxoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-N-cyclohexyl-2-oxoacetamide(1029542-48-0)
• EPA Substance Registry System: 2-(4-bromophenyl)-N-cyclohexyl-2-oxoacetamide(1029542-48-0)

Safety Data

• Hazardous Substances Data: 1029542-48-0(Hazardous Substances Data)

Upstream product

• 931-53-3 Cyclohexyl isocyanide 
• 1122-91-4 4-bromo-benzaldehyde 
• 1218933-56-2 2?(4?bromophenyl)?N?cyclohexylimidazo[1,2?a]pyridin?3?amine 
• 1029542-36-6 C₂₃H₂₈BrN₃O₄ 

Relevant articles and documents

Copper-catalyzed oxidative cleavage of Passerini and Ugi adducts in basic medium yielding α-ketoamides

The aerobic oxidative cleavage of Passerini and Ugi adducts in the presence of base and copper(i) iodide is studied in detail. The oxidative cleavage yields α-ketoamides along with acids and amides from Passerini and Ugi adducts respectively. Mechanistic investigations revealed that the reaction proceeds via a radical pathway involving molecular oxygen. Control experiments with 18O-labeled Passerini adducts confirmed that molecular oxygen is the source of oxygen in α-ketoamides. A variety of Passerini and Ugi adducts were studied to explore the effect of substitution. Overall, the present study provides an insight into the reactivity of Passerini and Ugi adducts in strong basic conditions along with a method to prepare α-ketoamides.

Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides

An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.

New palladium-catalyzed aerobic oxidative cleavage and cyclization of N-aryl peptide derivatives

Oxidative cleavage and cyclization cascades of N-aryl peptides have been achieved under palladium catalysis with air as the sole stoichiometric oxidant. The Royal Society of Chemistry.