1029654-30-5 Usage
Uses
Used in Medicinal Chemistry and Drug Development:
(2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID is used as a building block for the synthesis of complex molecules, leveraging its boronic acid group to form covalent bonds with different substrates. This property is particularly valuable in the creation of new pharmaceutical agents.
Used in Organic Chemistry:
As a modifier of reactivity and electronic properties, (2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID is used to fine-tune the characteristics of organic compounds, which can be crucial for optimizing their performance in various chemical reactions and applications.
Used in Biochemical Research:
(2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID is employed as a tool to form reversible covalent complexes with biological molecules such as sugars and amino acids. This capability is useful in studying the interactions and mechanisms involving these molecules in biological systems.
Used in Chemical Synthesis:
(2-FLUORO-4-METHYLPYRIDIN-3-YL)BORONIC ACID is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds, taking advantage of its ability to participate in various chemical reactions due to its functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 1029654-30-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,9,6,5 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1029654-30:
(9*1)+(8*0)+(7*2)+(6*9)+(5*6)+(4*5)+(3*4)+(2*3)+(1*0)=145
145 % 10 = 5
So 1029654-30-5 is a valid CAS Registry Number.
1029654-30-5Relevant academic research and scientific papers
Preparation method of 2-fluoro-4-methyl-3-pyridinylboronic acid
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Paragraph 0010; 0016-0027, (2018/06/15)
The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 2-fluoro-4-methyl-3-pyridinylboronic acid. The preparation method comprises the following steps: performing a lithium-halogen exchange reaction and a boronizing reaction on 2-fluoro-3-bromo-4-methylpyridine serving as a raw material, a lithiation agent and a boronizing agent at alow temperature through a one-pot method to obtain 2-fluoro-4-methyl-3-pyridine ester borate; dehydrating the prepared 2-fluoro-4-methyl-3-pyridine ester borate with a 10 percent by mass sodium hydroxide aqueous solution to obtain a 2-fluoro-4-methyl-3-pyridinylboronic acid crude product; purifying the 2-fluoro-4-methyl-3-pyridinylboronic acid crude product to obtain a 2-fluoro-4-methyl-3-pyridinylboronic acid pure product. In the reaction, tetrahydrofuran is taken as a reaction solvent. The preparation method of the 2-fluoro-4-methyl-3-pyridinylboronic acid has the advantages of low cost, adoption of readily-available raw materials, mild reaction conditions, simple post-treatment operation, lower production cost, high yield, lower reaction cost, and suitability for industrial production.
