10299-43-1

Basic information

• Product Name: 9-[2,3-O-(1-methylethylidene)-5-O-tritylpentofuranosyl]-9H-purin-6-amine
• CAS NO: 10299-43-1
• Molecular Formula: C₃₂H₃₁N₅O₄
• Molecular Weight: 549.6196
• Mol File: 10299-43-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 725°C at 760 mmHg
• Flash Point: 392.3°C
• Density: 1.36g/cm³
• Vapor Pressure: 7.13E-21mmHg at 25°C
• Refractive Index: 1.684
• CAS DataBase Reference: 9-[2,3-O-(1-methylethylidene)-5-O-tritylpentofuranosyl]-9H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[2,3-O-(1-methylethylidene)-5-O-tritylpentofuranosyl]-9H-purin-6-amine(10299-43-1)
• EPA Substance Registry System: 9-[2,3-O-(1-methylethylidene)-5-O-tritylpentofuranosyl]-9H-purin-6-amine(10299-43-1)

Safety Data

• Hazardous Substances Data: 10299-43-1(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 362-75-4 2',3'-isopropylidene adenosine 

Relevant articles and documents

Regioselective alkylation of the exocyclic nitrogen of adenine and adenosine by the Mitsunobu reaction

A novel synthetic route to N6-substitution of adenine is presented, employing the Mitsunobu reaction as the key step. A range of primary and secondary alcohols all coupled in very good to excellent yields within 30 min at 45 °C, offering a milder alternative to the traditional nucleophilic aromatic substitution of 6-chloropurine. The utility of this protocol is further demonstrated by its application to the syntheses of N6,N9-di-substituted adenines, including the potent and selective A1 adenosine receptor agonist N6-cyclopentyladenosine.