1030030-76-2Relevant academic research and scientific papers
The first entry to pyrrolo[2,3-c]quinoline-2,4(3aH,5H)-diones
Kafka, Stanislav,Klásek, Antonín,Polis, Ji?í,Rosenbreierová, Veronika,Palík, Ctibor,Mrkvi?ka, Vladimír,Ko?mrlj, Janez
, p. 4387 - 4402 (2008/09/20)
Wittig olefination of 3-aminoquinoline-2,4(1H,3H)-diones 1 with ethyl (triphenylphosphoranylidene)acetate (Ph3P{double bond, long}CHCO2Et) afforded (E)-3-amino-4-ethoxycarbonylmethylene-1,2,3,4-tetrahydro-2-quinolones (E)-2 and pyrrolo[2,3-c]quinoline-2,4(3aH,5H)-diones 3. An alternative approach for the synthesis of 3 via 3-bromoacetamidoquinoline-2,4(1H,3H)-diones 7, their corresponding triphenylphosphonium salts 8, and ylides A that undergo intramolecular Wittig reaction, was investigated. Under the applied reaction conditions, the phosphonium salts 8 and ylides A are so unstable that they partly decompose to 3-acetamidoquinoline-2,4(1H,3H)-diones 9 during the synthesis of 3.
