1030364-10-3Relevant academic research and scientific papers
Examination of the structure in solid state of amino analogs of 4,4′-[1,5-pentanediylbis(oxy)]bisbenzonitrile by means of X-ray diffraction, 13C CP/MAS NMR, and theoretical calculations
Maciejewska, Dorota,Wolska, Irena,Zabiński, Jerzy
, p. 53 - 59 (2008)
A single crystal of X-ray diffraction structures is presented for 4,4′-[1,5-(3-oxapentanediylbis(amino))]bisbenzonitrile 2 and 4,4′-[1,5-(N-methyl-3-azapentane-diylbis(oxy))]bisbenzonitrile 3. The molecular structures of these derivatives differ especially in conformations of the central linker: in 2 this linker adopts a trans/gauche conformation, whereas in 3 - a fully extended conformation. The N atoms in various positions of the aliphatic linker change dramatically the molecular packing mode of both bisnitriles. But in both cases the nitrile groups take part in intermolecular hydrogen bonds: a type of N{single bond}H···N in 2 and of C{single bond}H···N in 3. Various conformations of both molecules were reflected in 13C CP/MAS NMR spectra in solid state as single and double resonance patterns for 2 and 3, respectively. A preliminary anticancer assay against 60 cell lines of 3 reveals strong growth inhibition of leukemia, melanoma, and renal cancer cells.
Analogs of pentamidine as potential anti-Pneumocystis chemotherapeutics
MacIejewska, Dorota,Zabinski, Jerzy,Ka?mierczak, Pawel,Rezler, Mateusz,Krassowska-?wiebocka, Barbara,Collins, Margaret S.,Cushion, Melanie T.
scheme or table, p. 164 - 173 (2012/03/26)
A series of 20 pentamidine analogs were prepared using 2 general Schemes that evaluated heteroatoms, sulfobenzene and alkanediamide groups in the aliphatic linker and methoxy substituents attached to the benzene rings for efficacy against the fungal patho
