1030379-26-0

Basic information

• Product Name: (2R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-aziridine-2-carboxylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
• CAS NO: 1030379-26-0
• Molecular Weight: 536.627
• Mol File: 1030379-26-0.mol

Chemical Properties

• CAS DataBase Reference: (2R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-aziridine-2-carboxylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-aziridine-2-carboxylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester(1030379-26-0)
• EPA Substance Registry System: (2R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-aziridine-2-carboxylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester(1030379-26-0)

Safety Data

• Hazardous Substances Data: 1030379-26-0(Hazardous Substances Data)

Upstream product

• 1875-48-5 N-aminophthalamide 
• 760197-32-8 acrylic acid 1-[hydroxy(diphenyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 

Relevant articles and documents

On the scope of diastereoselective aziridination of various chiral auxiliaries derived N- and O-enones with N-aminophthalimide in the presence of lead tetraacetate

The treatment of a range of N- and O-enones derived from various camphor-based chiral auxiliaries A-D with N-aminophthalimide in the presence of lead tetraacetate is described. In general, N-phthalimidoaziridines were obtained with high diastereoselectivities (up to 98% de) and chemical yields (up to 95%) when 10,10-diphenyl-2,10-camphanediol A derived O-enones with a range of substituents were used under the same reaction conditions. Excellent stereoselectivity was obtained when the N-tosyl camphorpyrazolidinone E derived acrylate was used. The absolute configuration of the new stereogenic center(s) of the major diastereomer was established by X-ray crystallographic analysis. Chiral auxiliary cleavage was achieved under mild reaction conditions. A model to explain the stereochemical induction is also proposed.