1030431-70-9 Usage
Description
4-Chloro-2-isopropyl-6-methylpyrimidine is an organic compound that serves as a crucial intermediate in the synthesis of various pyrimidine derivatives. It is characterized by its unique molecular structure, which includes a chlorine atom at the 4th position, an isopropyl group at the 2nd position, and a methyl group at the 6th position on the pyrimidine ring. 4-CHLORO-2-ISOPROPYL-6-METHYLPYRIMIDINE is known for its potential applications in the pharmaceutical and chemical industries due to its antifungal properties.
Uses
Used in Pharmaceutical Industry:
4-Chloro-2-isopropyl-6-methylpyrimidine is used as an intermediate for the synthesis of novel pyrimidine derivatives that exhibit antifungal activities. These derivatives are valuable in the development of new antifungal drugs to combat various fungal infections.
Used in Chemical Industry:
In the chemical industry, 4-chloro-2-isopropyl-6-methylpyrimidine can be utilized as a building block for the creation of more complex molecules with diverse applications. Its unique structure allows for further functionalization and modification, making it a versatile compound for research and development in the chemical sector.
Check Digit Verification of cas no
The CAS Registry Mumber 1030431-70-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,0,4,3 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1030431-70:
(9*1)+(8*0)+(7*3)+(6*0)+(5*4)+(4*3)+(3*1)+(2*7)+(1*0)=79
79 % 10 = 9
So 1030431-70-9 is a valid CAS Registry Number.
1030431-70-9Relevant articles and documents
Covalent inhibition of the histamine H3 receptor
Wágner, Gábor,Mocking, Tamara A.M.,Kooistra, Albert J.,Slynko, Inna,ábrányi-Balogh, Péter,Keser u, Gy?rgy M.,Wijtmans, Maikel,Vischer, Henry F.,de Esch, Iwan J.P.,Leurs, Rob
, (2019)
Covalent binding of G protein-coupled receptors by small molecules is a useful approach for better understanding of the structure and function of these proteins. We designed, synthesized and characterized a series of 6 potential covalent ligands for the histamine H3 receptor (H3R). Starting from a 2-amino-pyrimidine scaffold, optimization of anchor moiety and warhead followed by fine-tuning of the required reactivity via scaffold hopping resulted in the isothiocyanate H3R ligand 44. It shows high reactivity toward glutathione combined with appropriate stability in water and reacts selectively with the cysteine sidechain in a model nonapeptide equipped with nucleophilic residues. The covalent interaction of 44 with H3R was validated with washout experiments and leads to inverse agonism on H3R. Irreversible binder 44 (VUF15662) may serve as a useful tool compound to stabilize the inactive H3R conformation and to study the consequences of prolonged inhibition of the H3R.
